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DNMT inhibitors increase methylation at subset of CpGs in colon, bladder, lymphoma, breast, and ovarian, cancer genome

2018-08-25

Abstract excerpt

<h4>Background</h4> DNA methyltransferase inhibitors (DNMTi) decitabine and azacytidine are approved therapies for acute myeloid leukemia and myelodysplastic syndrome. Identification of CpGs violating demethylaion due to DNMTi treatment may help to understand their resistance mechanisms. <h4>Materials and Methods</h4> To identify such CpGs, we analysed publicly available 450K methylation data of multiple cancer...

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Literature Corpus work
4dc77ea9-3847-5fdf-a1c0-4c554495422f
DOI
10.1101/395467
Open publication

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