Article

Examination of INPP5A in uveal melanoma uncovers novel calcium transients

2024-09-22

Abstract excerpt

Uveal melanoma is a highly aggressive intraocular cancer that metastasizes in about half of patients whereupon it is inexorably fatal. Uveal melanomas (UM) are distinct from other melanomas because they are driven by constitutively activating mutation in the heterotrimeric G protein alpha subunits Gq (GNAQ) and G11 (GNA11). This results in constitutive production of inositol trisphosphate (IP3) by phospholipase C-...

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Literature Corpus work: c8b755f2-cfeb-57c7-94a5-280ed2ad8d0d
DOI: 10.1101/2024.09.18.613756

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