Article
RasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma.
Cancer cell - 8 May 2017
Chen Xu, Wu Qiuxia, Depeille Philippe, Chen Peirong, Thornton Sophie, Kalirai Helen, Coupland Sarah E, Roose Jeroen P, Bastian Boris C
Abstract excerpt
Constitutive activation of Gαq signaling by mutations in GNAQ or GNA11 occurs in over 80% of uveal melanomas (UMs) and activates MAPK. Protein kinase C (PKC) has been implicated as a link, but the mechanistic details remained unclear. We identified PKC δ and ɛ as required and sufficient to activate MAPK in GNAQ mutant melanomas. MAPK activation depends on Ras and is caused by RasGRP3, which is significantly and...
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