Article
Protein Kinase Signaling Networks Driven by Oncogenic Gq/11 in Uveal Melanoma Identified by Phosphoproteomic and Bioinformatic Analyses.
Molecular & cellular proteomics : MCP - 1 Nov 2023
Onken Michael D, Erdmann-Gilmore Petra, Zhang Qiang, Thapa Kisan, King Emily, Kaltenbronn Kevin M, Noda Sarah E, Makepeace Carol M, Goldfarb Dennis, Babur Özgün, Townsend R Reid, Blumer Kendall J
Abstract excerpt
Metastatic uveal melanoma (UM) patients typically survive only 2 to 3 years because effective therapy does not yet exist. Here, to facilitate the discovery of therapeutic targets in UM, we have identified protein kinase signaling mechanisms elicited by the drivers in 90% of UM tumors: mutant constitutively active G protein α-subunits encoded by GNAQ (Gq) or GNA11 (G11). We used the highly specific Gq/11 inhibitor...
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