Disruption of the interaction between mutationally activated Gαq and Gβγ attenuates aberrant signaling.

Abstract excerpt

Heterotrimeric G protein stimulation via G protein-coupled receptors promotes downstream proliferative signaling. Mutations can occur in Gα proteins which prevent GTP hydrolysis; this allows the G proteins to signal independently of G protein-coupled receptors and can result in various cancers, such as uveal melanoma (UM). Most UM cases harbor Q209L, Q209P, or R183C mutations in Gαq/11 proteins, rendering the...

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• Share to GTP-Binding Protein alpha Subunits, Gq-G11
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