Article
Novel Protein Kinase C-Mediated Control of Orai1 Function in Invasive Melanoma.
Molecular and cellular biology - 1 Aug 2015
Hooper Robert, Zhang Xuexin, Webster Marie, Go Christina, Kedra Joseph, Marchbank Katie, Gill Donald L, Weeraratna Ashani T, Trebak Mohamed, Soboloff Jonathan
Abstract excerpt
The incidence of malignant melanoma, a cancer of the melanocyte cell lineage, has nearly doubled in the past 20 years. Wnt5A, akey driver of melanoma invasiveness, induces Ca2 signals. To understand how store-operated calcium entry (SOCE) contributes to Wnt5A-induced malignancy in melanoma models, we examined the expression and function of STIM1 and Orai1 in patient-derived malignant melanoma cells, previously...
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