Article
Mutant Gq/11 promote uveal melanoma tumorigenesis by activating YAP.
Cancer cell - 16 Jun 2014
Yu Fa-Xing, Luo Jing, Mo Jung-Soon, Liu Guangbo, Kim Young Chul, Meng Zhipeng, Zhao Ling, Peyman Gholam, Ouyang Hong, Jiang Wei, Zhao Jiagang, Chen Xu, Zhang Liangfang, Wang Cun-Yu, Bastian Boris C, Zhang Kang, Guan Kun-Liang
Abstract excerpt
Uveal melanoma (UM) is the most common cancer in adult eyes. Approximately 80% of UMs harbor somatic activating mutations in GNAQ or GNA11 (encoding Gq or G11, respectively). Herein, we show in both cell culture and human tumors that cancer-associated Gq/11 mutants activate YAP, a major effector of the Hippo tumor suppressor pathway that is also regulated by G protein-coupled receptor signaling. YAP mediates the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.