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Article

NRAS Mutant Dictates AHCYL1-Governed ER Calcium Homeostasis for Melanoma Tumor Growth.

Molecular cancer research : MCR - 2 Apr 2024

Cai Chufan, Tu Jiayi, Najarro Jeronimo, Zhang Rukang, Fan Hao, Zhang Freya Q, Li Jiacheng, Xie Zhicheng, Su Rui, Dong Lei, Arellano Nicole, Ciboddo Michele, Elf Shannon E, Gao Xue, Chen Jing, Wu Rong

Abstract excerpt

Calcium homeostasis is critical for cell proliferation, and emerging evidence shows that cancer cells exhibit altered calcium signals to fulfill their need for proliferation. However, it remains unclear whether there are oncogene-specific calcium homeostasis regulations that can expose novel therapeutic targets. Here, from RNAi screen, we report that adenosylhomocysteinase like protein 1 (AHCYL1), a suppressor of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38294692
DOI: 10.1158/1541-7786.MCR-23-0445
PMCID: PMC10987265

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