Article
Adults with Philadelphia chromosome-like acute lymphoblastic leukemia frequently have IGH-CRLF2 and JAK2 mutations, persistence of minimal residual disease and poor prognosis.
Haematologica - 1 Jan 2017
Herold Tobias, Schneider Stephanie, Metzeler Klaus H, Neumann Martin, Hartmann Luise, Roberts Kathryn G, Konstandin Nikola P, Greif Philipp A, Bräundl Kathrin, Ksienzyk Bianka, Huk Natalia, Schneider Irene, Zellmeier Evelyn, Jurinovic Vindi, Mansmann Ulrich, Hiddemann Wolfgang, Mullighan Charles G, Bohlander Stefan K, Spiekermann Karsten, Hoelzer Dieter, Brüggemann Monika, Baldus Claudia D, Dreyling Martin, Gökbuget Nicola
Abstract excerpt
Philadelphia-like B-cell precursor acute lymphoblastic leukemia (Ph-like ALL) is characterized by distinct genetic alterations and inferior prognosis in children and younger adults. The purpose of this study was a genetic and clinical characterization of Ph-like ALL in adults. Twenty-six (13%) of 207 adult patients (median age: 42 years) with B-cell precursor ALL (BCP-ALL) were classified as having Ph-like ALL...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.