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How I treat Philadelphia chromosome–like acute lymphoblastic leukemia in children, adolescents, and young adults

24 Apr 2024

Abstract excerpt

ABSTRACT: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) represents a high-risk B-lineage ALL subtype characterized by adverse clinical features and poor relapse-free survival despite risk-adapted multiagent chemotherapy regimens. The advent of next-generation sequencing has unraveled the diversity of kinase-activating genetic drivers in Ph-like ALL that are potentially amenable to...

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Identifiers

PMID: 38657263
DOI: 10.1182/blood.2023023153

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