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BRG1 promotes progression of B-cell acute lymphoblastic leukemia by disrupting PPP2R1A transcription

26 Aug 2024

Abstract excerpt

Despite advancements in chemotherapy and the availability of novel therapies, the outcome of adult patients with B-cell acute lymphoblastic leukemia (B-ALL) remains unsatisfactory. Therefore, it is necessary to understand the molecular mechanisms underlying the progression of B-ALL. Brahma-related gene 1 (BRG1) is a poor prognostic factor for multiple cancers. Here, the expression of BRG1 was found to be higher...

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PMID: 39187513
DOI: 10.1038/s41419-024-06996-w

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