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Article

Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure

1 Apr 2021

Abstract excerpt

Ageing is a major risk factor for the development of cardiovascular disease (CVD) and cancer. Whilst the cumulative effect of exposure to conventional cardiovascular risk factors is important, recent evidence highlights clonal haematopoiesis of indeterminant potential (CHIP) as a further key risk factor. CHIP reflects the accumulation of somatic, potentially pro-leukaemic gene mutations within haematopoietic stem...

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PMID: 33861346
DOI: 10.1042/cs20200306

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