Article
Clonal hematopoiesis and cardiovascular disease: deciphering interconnections.
Basic research in cardiology - 10 Nov 2022
Stein Anna, Metzeler Klaus, Kubasch Anne Sophie, Rommel Karl-Philipp, Desch Steffen, Buettner Petra, Rosolowski Maciej, Cross Michael, Platzbecker Uwe, Thiele Holger
Abstract excerpt
Cardiovascular and oncological diseases represent the global major causes of death. For both, a novel and far-reaching risk factor has been identified: clonal hematopoiesis (CH). CH is defined as clonal expansion of peripheral blood cells on the basis of somatic mutations, without overt hematological malignancy. The most commonly affected genes are TET2, DNMT3A, ASXL1 and JAK2. By the age of 70, at least 20-50%...
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