Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease.

doi:10.1016/j.jacc.2023.03.401

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Article

Clonal Hematopoiesis of Indeterminate Potential Predicts Adverse Outcomes in Patients With Atherosclerotic Cardiovascular Disease.

Journal of the American College of Cardiology - 23 May 2023

Gumuser Esra D, Schuermans Art, Cho So Mi Jemma, Sporn Zachary A, Uddin Md Mesbah, Paruchuri Kaavya, Nakao Tetsushi, Yu Zhi, Haidermota Sara, Hornsby Whitney, Weeks Lachelle D, Niroula Abhishek, Jaiswal Siddhartha, Libby Peter, Ebert Benjamin L, Bick Alexander G, Natarajan Pradeep, Honigberg Michael C

Abstract excerpt

BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP)-the age-related clonal expansion of blood stem cells with leukemia-associated mutations-is a novel cardiovascular risk factor. Whether CHIP remains prognostic in individuals with established atherosclerotic cardiovascular disease (ASCVD) is less clear. OBJECTIVES: This study tested whether CHIP predicts adverse outcomes in individuals with...

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PMID: 37197843
DOI: 10.1016/j.jacc.2023.03.401
PMCID: PMC10249057

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