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B7x—from bench to bedside

1 Jan 2019

Abstract excerpt

B7x is an immune checkpoint molecule which belongs to the B7 family of ligands which includes PD-L1, PD-L2, B7-H3 and HHLA2. B7x belongs to the Immunoglobulin superfamily and its protein structure is similar to other members with a N terminus peptide, IgV and IgC like extracellular domain with four cysteine residues. Its receptor is yet to be identified. B7x inhibits T cell proliferation and expansion by IL-2...

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Identifiers

PMID: 31555486
DOI: 10.1136/esmoopen-2019-000554

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