Article

Integrative molecular analyses define the genomic, transcriptomic, and epigenomic correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancer

2022-06-17

Abstract excerpt

B7-H3 (CD276) is an immune checkpoint overexpressed in prostate cancer with minimal expression in normal tissues and associated with poor prognosis, making it an excellent therapy target. We interrogated B7-H3 expression and its regulation in metastatic castration-resistant prostate cancer (mCRPC). We found greater expression of B7-H3 transcript relative to other immunotherapy targets (CTLA4, PD-L1/2), including i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e1cfd0d3-8eb5-5010-8282-b883073a1c37
DOI: 10.21203/rs.3.rs-1726587/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Integrative molecular analyses define the genomic, transcriptomic, and epigenomic correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancerDOI 10.21203/rs.3.rs-1726587/v1Read

Integrative molecular analyses define correlates of high B7-H3 expression in metastatic castrate-resistant prostate cancerSemantic proximity Read

Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancerSemantic proximity Read

Association of B7‐H3 expression with racial ancestry, immune cell density, and androgen receptor activation in prostate cancerSemantic proximity Read

To kill a cancer: Targeting the immune inhibitory checkpoint molecule, B7-H3Semantic proximity Read

Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progressionSemantic proximity Read

Large-scale analysis reveals the specific clinical and immune features of B7-H3 in gliomaSemantic proximity Read

Epigenetic and transcriptional analysis reveals a core transcriptional program conserved in clonal prostate cancer metastasesSemantic proximity Read

CDH3 as a Novel Therapeutic Target in Basal-like Double-Negative Prostate CancerSemantic proximity Read

Genetic wiring of the m6A epitranscriptome drives prostate cancer progressionSemantic proximity Read

Predicting Prostate Adenocarcinoma Patients’ Survival and Immune Signature: A Novel Risk Model Based on Telomere-Related GenesSemantic proximity Read

B7-H3 specific CAR-T cells exhibit potent activity against prostate cancerSemantic proximity Read

Genetic and clinical characterization of B7‐H3 (CD276) expression and epigenetic regulation in diffuse brain gliomaSemantic proximity Read