Deciphering the suppressive immune microenvironment of prostate cancer based on CD4+ regulatory T cells: Implications for prognosis and therapy prediction

Abstract excerpt

Dear Editor, Prostate cancer (PCa) is traditionally considered an immunologically cold tumour characterized by an immunosuppressive tumour microenvironment (TME) and a disappointing response to immunotherapy. Nevertheless, recent studies have demonstrated that the TME of PCa is heterogeneous, and some PCa patients still exhibit “hot tumours” and are sensitive to immunotherapy.1 Our prior works also classified PCa...

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• Cancer Immunotherapy and Biomarkers
• Immunotherapy and Immune Responses
• T-cell and B-cell Immunology