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Article

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaks

4 Jul 2019

Abstract excerpt

PARP-1 is rapidly recruited and activated by DNA double-strand breaks (DSBs). Upon activation, PARP-1 synthesizes a structurally complex polymer composed of ADP-ribose units that facilitates local chromatin relaxation and the recruitment of DNA repair factors. Here, we identify a function for PARP-1 in DNA DSB resection. Remarkably, inhibition of PARP-1 leads to hyperresected DNA DSBs. We show that loss of PARP-1...

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PMID: 31273204
DOI: 10.1038/s41467-019-10741-9

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