Article

Genome based subtyping identifies Parkinson’s disease subtypes with reproducible motor progression differences and clinical trial enrichment potential

2026-07-10

Abstract excerpt

<title>Abstract</title> <p>Parkinson’s disease (PD) is clinically and biologically heterogeneous. We tested whether polygenic variation alone could identify early PD subtypes with distinct longitudinal outcomes and replication cohorts. We analyzed whole genome sequencing from 1,419 participants across the Parkinson’s Progression Markers Initiative (PPMI), Parkinson’s Disease Biomarkers Program (PDBP), and STEADY-...

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Literature Corpus work: 1c123bc7-ede7-5147-aa1b-15f7a969da44
DOI: 10.21203/rs.3.rs-10167910/v1

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