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Article

APOBEC3G hypermutates genomic DNA and inhibits Ty1 retrotransposition in yeast.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jul 2005

Schumacher April J, Nissley Dwight V, Harris Reuben S

Abstract excerpt

Human cells harbor a variety of factors that function to block the proliferation of foreign nucleic acid. The APOBEC3G enzyme inhibits the replication of retroviruses by deaminating nascent retroviral cDNA cytosines to uracils, lesions that can result in lethal levels of hypermutation. Here, we demonstrate that APOBEC3G is capable of deaminating genomic cytosines in Saccharomyces cerevisiae. APOBEC3G expression...

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Identifiers

PMID: 16000409
DOI: 10.1073/pnas.0501694102
PMCID: PMC1172225

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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