The Diversity and Molecular Evolution of B-Cell Receptors during Infection.

doi:10.1093/molbev/msw015

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

The Diversity and Molecular Evolution of B-Cell Receptors during Infection.

Molecular biology and evolution - 1 May 2016

Hoehn Kenneth B, Fowler Anna, Lunter Gerton, Pybus Oliver G

Abstract excerpt

B-cell receptors (BCRs) are membrane-bound immunoglobulins that recognize and bind foreign proteins (antigens). BCRs are formed through random somatic changes of germline DNA, creating a vast repertoire of unique sequences that enable individuals to recognize a diverse range of antigens. After encountering antigen for the first time, BCRs undergo a process of affinity maturation, whereby cycles of rapid somatic...

Topics

Adaptive Immunity
Antibody Affinity
B-Lymphocytes
Evolution, Molecular
Genetic Variation
High-Throughput Nucleotide Sequencing
Humans
Immunoglobulins
Infections
Membrane Proteins
Mutation
Receptors, Antigen, B-Cell

Source

Open in PubMed Open full text

Identifiers

PMID: 26802217
DOI: 10.1093/molbev/msw015
PMCID: PMC4839220

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics