Article

Phage Peptides Mediate Precision Base Editing with Focused Targeting Window

2020-11-02

Abstract excerpt

Cytidine base editors (CBE) are novel genome engineering tools that can generate C-to-T nucleotide substitutions without introducing double-stranded breaks (DSBs). Instead of generating single-point mutations, CBEs induce nucleotide substitutions at wobble positions within the 20-nucleotide target site. A variety of strategies have been developed to improve the targeting scope and window of CBEs. Among these strat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c7facf93-3dcc-5505-bdd9-b3156b851ae5
DOI: 10.1101/2020.11.02.364430

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Phage Peptides Mediate Precision Base Editing with Focused Targeting WindowDOI 10.1101/2020.11.02.364430Read

Phage peptides mediate precision base editing with focused targeting window.Semantic proximity Read

Engineering precise adenine base editor with infinitesimal rates of bystander mutations and off-target editingSemantic proximity Read

Engineering a precise adenine base editor with minimal bystander editing.Semantic proximity Read

An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities.Semantic proximity Read

Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity.Semantic proximity Read

Breaking genetic shackles: The advance of base editing in genetic disorder treatmentSemantic proximity Read

CRISPR-Cas9 DNA Base-Editing and Prime-Editing.Semantic proximity Read

Targeted RNA base editing for therapeutic: mechanisms and advancesSemantic proximity Read

A motif preferred adenine base editor with minimal bystander and off-targets editingSemantic proximity Read

Efficient precise <i>in vivo</i> base editing in adult dystrophic miceSemantic proximity Read

Phage DNA polymerase prevents deleterious on-target DNA damage and enhances precise CRISPR/Cas9 editingSemantic proximity Read

In the business of base editors: Evolution from bench to bedsideSemantic proximity Read