Article
Phage peptides mediate precision base editing with focused targeting window.
Nature communications - 29 Mar 2022
Jia Kun, Cui Yan-Ru, Huang Shisheng, Yu Peihong, Lian Zhengxing, Ma Peixiang, Liu Jia
Abstract excerpt
Base editors (BEs) are genome engineering tools that can generate nucleotide substitutions without introducing double-stranded breaks (DSBs). A variety of strategies have been developed to improve the targeting scope and window of BEs. In a previous study, we found that a bacteriophage-derived peptide, referred to as G8PPD, could improve the specificity of Cas9 nuclease. Herein, we investigate the applicability...
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