Article
Individualized strategies to target specific mechanisms of disease in malignant melanoma patients displaying unique mutational signatures.
Oncotarget - 22 Sept 2015
Curiel-Olmo Soraya, García-Castaño Almudena, Vidal Rebeca, Pisonero Helena, Varela Ignacio, León-Castillo Alicia, Trillo Eugenio, González-Vela Carmen, García-Diaz Nuria, Almaraz Carmen, Moreno Thaidy, Cereceda Laura, Madureira Rebeca, Martinez Nerea, Ortiz-Romero Pablo, Valdizán Elsa, Piris Miguel A, Vaqué José P, Piris Miguel, Vaqué José
Abstract excerpt
Targeted treatment of advanced melanoma could benefit from the precise molecular characterization of melanoma samples. Using a melanoma-specific selection of 217 genes, we performed targeted deep sequencing of a series of biopsies, from advanced melanoma cases, with a Breslow index of ≥ 4 mm, and/or with a loco-regional infiltration in lymph nodes or presenting distant metastasis, as well of a collection of human...
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