Article
Genomic and signalling pathway characterization of the NZM panel of melanoma cell lines: A valuable model for studying the impact of genetic diversity in melanoma.
Pigment cell & melanoma research - 1 Jan 2021
Tran Khanh B, Gimenez Gregory, Tsai Peter, Kolekar Sharada, Rodger Euan J, Chatterjee Aniruddha, Jabed Anower, Shih Jen-Hsing, Joseph Wayne R, Marshall Elaine S, Wang Qian, Print Cristin G, Eccles Michael R, Baguley Bruce C, Shepherd Peter R
Abstract excerpt
Melanoma is a disease associated with a very high mutation burden and thus the possibility of a diverse range of oncogenic mechanisms that allow it to evade therapeutic interventions and the immune system. Here, we describe the characterization of a panel of 102 cell lines from metastatic melanomas (the NZM lines), including using whole-exome and RNA sequencing to analyse genetic variants and gene expression...
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