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Article

TMEM173 variants and potential importance to human biology and disease.

Genes and immunity - 1 Jan 2019

Patel Seema, Jin Lei

Abstract excerpt

TMEM173 gene encodes the protein STING (stimulator of interferon genes), a key player in host defense against pathogens. Mutations in the human TMEM173 gene cause a life-threatening auto-inflammatory disease called SAVI (STING-associated vasculopathy with onset in infancy). Human STING is also a promising therapeutic target for cancers and infectious diseases. Recently, Aduro Biotech and Novartis announced a...

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Identifiers

PMID: 29728611
DOI: 10.1038/s41435-018-0029-9
PMCID: PMC6212339

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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