Article

Peptide-Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical Progress

2025-03-20

Abstract excerpt

Peptide-drug conjugates (PDCs) have emerged as a next-generation therapeutic platform, combining the target specificity of peptides with the pharmacological potency of small-molecule drugs. As an evolution beyond antibody-drug conjugates (ADCs), PDCs offer distinct advantages, including enhanced cellular permeability, improved drug selectivity, and versatile design flexibility. This review provides a comprehensive...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba4fd925-9a8f-51d2-b2cc-084173ab24d7
DOI: 10.20944/preprints202503.1521.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Peptide-Drug Conjugates as Next-Generation Therapeutics: Exploring the Potential and Clinical ProgressDOI 10.20944/preprints202503.1521.v1Read

Anticancer Peptides: Design Principles, Translational Bottlenecks, and Emerging OpportunitiesSemantic proximity Read

Linker Design in Antibody-Drug Conjugates: Balancing Stability, Release and ResistanceSemantic proximity Read

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates.Semantic proximity Read

Modular platform for therapeutic drug delivery using trifunctional bio-orthogonal macromolecular conjugatesSemantic proximity Read

Expanding the repertoire of Antibody Drug Conjugate (ADC) targets with improved tumor selectivity and range of potent payloads through in-silico analysis.Semantic proximity Read

From Small Molecules to Degraders and AI: Contemporary Trends and Future Directions in Anticancer Drug DiscoverySemantic proximity Read

From Small Molecules to Degraders and AI: Contemporary Trends and Future Directions in Anticancer Drug DiscoverySemantic proximity Read

Precision medicine by designer interference peptides: applications in oncology and molecular therapeuticsSemantic proximity Read

Self‐Assembled L–DNA Linkers for Rapid Construction of Multi‐Specific Antibody‐Drug Conjugates LibrarySemantic proximity Read

Clinical Potential of Antibody–Drug Conjugates in Early-Phase Clinical Trials for Late-Line Treatment of Advanced Solid TumorsSemantic proximity Read

Extreme Hydrophobicity of Cytotoxic Drugs Enables Design of Next Generation Antibody-Drug Conjugates NanotherapeuticsSemantic proximity Read

Expanding the Reach of Monoclonal Antibodies: A Review of Synthetic Nucleic Acid Delivery in ImmunotherapySemantic proximity Read