Welding PROxAb Shuttles: A modular approach for generating bispecific antibodies via site-specific protein-protein conjugation

Abstract excerpt

Targeted protein degradation is an innovative therapeutic strategy to selectively eliminate disease-causing proteins. Exemplified by proteolysis-targeting chimeras (PROTACs), it has shown promise in overcoming drug resistance and targeting previously undruggable proteins. However, PROTACs face challenges such as low oral bioavailability and limited selectivity. The recently published PROxAb Shuttle technology offe...

Topics

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• Carcinoma, Non-Small-Cell Lung
• Cetuximab
• Down-Regulation
• ErbB Receptors
• Peptidase Inhibition and Analysis
• Protein Degradation and Inhibitors
• Proteolysis
• Ubiquitin and proteasome pathways

Identifiers and source

Literature Corpus work

5fb550b8-8f24-5f52-aa63-aea0af5dfbc8

DOI

10.1101/2024.03.15.585232