Affinity‐Directed Site‐Specific Protein Labeling and Its Application to Antibody‐Drug Conjugates

Abstract excerpt

Chemically modified proteins have diverse applications; however, conventional chemo-selective methods often yield heterogeneously labeled products. To address this limitation, site-specific protein labeling holds significant potential, driving extensive research in this area. Nevertheless, site-specific modification of native proteins remains challenging owing to the complexity of their functional groups....

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