<i>De Novo</i> Design of Peptide Masks Enables Rapid Generation of Conditionally-Active Miniprotein Binders

Abstract excerpt

<h4>ABSTRACT</h4> The widespread expression of many therapeutic targets in both diseased and healthy tissues presents a significant challenge for protein therapeutics, often resulting in dose-limiting side effects. To focus the action of biotherapeutics at the disease site, they can be reversibly inactivated by tethering an affinity mask through a linker cleavable by a disease-specific cue. However, current metho...

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• Acrylamides
• Agammaglobulinaemia Tyrosine Kinase
• Chemical Synthesis and Analysis
• Click Chemistry and Applications
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• Glycosylation and Glycoproteins Research
• Half-Life
• Monoclonal and Polyclonal Antibodies Research

Identifiers and source

Literature Corpus work

cc6c0118-9f59-5451-837e-9a49e0ce68c2

DOI

10.1101/2025.02.25.639922