Article

Deletion of Nrf1 exacerbates oxidative stress-induced cellular senescence by disrupting the cell homeostasis

2024-03-09

Abstract excerpt

Cellular senescence has been accepted as a fundamental contributor to ageing and a variety of age-related diseases, in which oxidative stress has been further recognized to play a critical initiation role. However, the anti-senescence potential of antioxidant nuclear factor erythroid-derived 2-like 1 (Nrf1, encoded by Nfe2l1 ) remains elusive to date, even though the hitherto accumulating evidence demonstrates th...

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Literature Corpus work: c7aa5f10-eb4a-5bf4-97be-a44ebad3843c
DOI: 10.1101/2024.03.09.584196

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