Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.

Aging cell - 1 Jun 2017

Wang Rong, Yu Zhen, Sunchu Bharath, Shoaf James, Dang Ivana, Zhao Stephanie, Caples Kelsey, Bradley Lynda, Beaver Laura M, Ho Emily, Löhr Christiane V, Perez Viviana I

Abstract excerpt

Senescent cells contribute to age-related pathology and loss of function, and their selective removal improves physiological function and extends longevity. Rapamycin, an inhibitor of mTOR, inhibits cell senescence in vitro and increases longevity in several species. Nrf2 levels have been shown to decrease with aging and silencing Nrf2 gene induces premature senescence. Therefore, we explored whether Nrf2 is...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to beta-Galactosidase
Share to Cyclin-Dependent Kinase Inhibitor p16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p21

Share to NF-E2-Related Factor 2

Share to Primary Cell Culture

Share to Sirolimus

Share to STAT3 Transcription Factor

Share to TOR Serine-Threonine Kinases

Source

Open in PubMed Open full text

Identifiers

PMID: 28371119
DOI: 10.1111/acel.12587
PMCID: PMC5418203

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.PMID 28371119Read ↗

Rapamycin and the inhibition of the secretory phenotype.Semantic proximity Read ↗

Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the LiverSemantic proximity Read ↗

The YAP-TEAD complex promotes senescent cell survival by lowering endoplasmic reticulum stressSemantic proximity Read ↗

MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.Semantic proximity Read ↗

Rapamycin decelerates cellular senescenceSemantic proximity Read ↗

Deletion of Nrf1 exacerbates oxidative stress-induced cellular senescence by disrupting the cell homeostasisSemantic proximity Read ↗

Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances.Semantic proximity Read ↗

Suppression of replicative senescence by rapamycin in rodent embryonic cellsSemantic proximity Read ↗

Ginsenoside Rb1 Relieves Cellular Senescence and Pulmonary Fibrosis by Promoting NRF2/QKI/SMAD7 AxisSemantic proximity Read ↗

Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term cultureSemantic proximity Read ↗

Autophagy Impairment Induces Premature Senescence in Primary Human FibroblastsSemantic proximity Read ↗

Insufficient autophagy in idiopathic pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.