Article
Cell proliferation arrest and redox state status as part of different stages during senescence establishment in mouse fibroblasts.
Biogerontology - 1 Apr 2014
Triana-Martínez Francisco, López-Diazguerrero Norma E, Maciel-Barón Luis A, Morales-Rosales Sandra L, Galván-Arzate Sonia, Fernandez-Perrino Francisco J, Zentella Alejandro, Pérez Viviana I, Gomez-Quiroz Luis E, Königsberg Mina
Abstract excerpt
Senescence phenotype can be achieved by multiple pathways. Most of them involve the activation of negative cell cycle regulators as well as a shift to an oxidative status. However, the exact participation of these events in senescence establishment and maintenance is not completely understood. In this study we investigated the content of three final cell cycle regulators, as well as the redox state in some...
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