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Article

E2F-1 is a critical modulator of cellular senescence in human cancer

1 May 2006

Abstract excerpt

Senescence limits cellular proliferation, and therefore might be a mechanism which could suppress the progression of cancer. Herein we show that E2F1, a transcription factor essential to a cell cycle progress and a main target of tumor suppressor Rb, is a critical barrier for the induction of senescence. Human cancer cells transfected with siE2F1 were shown to express replicative senescence markers, in addition...

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Share to Advanced biosensing and bioanalysis techniques
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Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 16596252
DOI: 10.3892/ijmm.17.5.715

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