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Article

The p38‐activated ER stress‐ATF6α axis mediates cellular senescence

27 Sept 2018

Abstract excerpt

The importance of proteostasis in preventing cellular senescence has been well recognized. However, the exact mechanism by which the loss of proteostasis or endoplasmic reticulum (ER) stress induces cellular senescence remains unclear. We report that ER stress mediates cellular senescence through the activating transcription factor (ATF)6α branch of the unfolded protein response (UPR). Cellular senescence was...

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PMID: 30260700
DOI: 10.1096/fj.201800836r

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