Article

Stem cell pathways and Notch signaling an emerging role in the development of acquired Drug Resistance in Neuroblastoma

2023-01-16

Abstract excerpt

<h4>Purpose: </h4> Neuroblastoma is a paediatric tumour that develops from embryonal neural crest cells that give rise to the sympathetic nervous system. Aggressive high-risk disease remains a clinical challenge and despite multi-modal therapy, survival rates are poor. Most neuroblastomas initially respond well to induction chemotherapy however, 50-60% of patients with high-risk disease will relapse with aggressiv...

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Literature Corpus work: e2d7ccf6-f826-5e85-91f0-a0063046b60e
DOI: 10.21203/rs.3.rs-2471355/v1

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