Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling.

International journal of cancer - 1 Nov 2004

Schmidt Wolfgang M, Kalipciyan Maria, Dornstauder Eva, Rizovski Blanka, Steger Guenther G, Sedivy Roland, Mueller Manfred W, Mader Robert M

Abstract excerpt

Resistance to anticancer drugs such as the widely used antimetabolite 5-fluorouracil (FU) is one of the most important obstacles to cancer chemotherapy. Using GeneChip arrays, we compared the expression profile of different stages of FU resistance in colon cancer cells after in vitro selection of low-, intermediate- and high-resistance phenotypes. Drug resistance was associated with significant changes in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antimetabolites, Antineoplastic
Share to Calcium-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cell Adhesion

Share to Collagen

Share to Colonic Neoplasms

Share to Down-Regulation

Share to Fluorouracil

Share to Keratins

Source

Identifiers

PMID: 15352031
DOI: 10.1002/ijc.20401

Genes

ABCC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dissecting progressive stages of 5-fluorouracil resistance in vitro using RNA expression profiling.PMID 15352031Read ↗

Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.Semantic proximity Read ↗

FOLFOXIRI Resistance Induction and Characterization in Human Colorectal Cancer CellsSemantic proximity Read ↗

Recent Updates on Mechanisms of Resistance to 5-Fluorouracil and Reversal Strategies in Colon Cancer TreatmentSemantic proximity Read ↗

Establishment and Characterization of 5-Fluorouracil-Resistant Human Colorectal Cancer Stem-Like Cells: Tumor Dynamics under Selection PressureSemantic proximity Read ↗

A Proteomic Investigation to Discover Candidate Proteins Involved in Novel Mechanisms of 5-Fluorouracil Resistance in Colorectal CancerSemantic proximity Read ↗

Deciphering cellular states of innate tumor drug responsesSemantic proximity Read ↗

Molecular and phenotypic characterization of 5-FU resistant colorectal cancer cells: toward enrichment of cancer stem cellsSemantic proximity Read ↗

Downregulation of KRAB zinc finger proteins in 5-fluorouracil resistant colorectal cancer cellsSemantic proximity Read ↗

Selective treatment pressure in colon cancer drives the molecular profile of resistant circulating tumor cell clonesSemantic proximity Read ↗

Comparison of gene expression in HCT116 treatment derivatives generated by two different 5-fluorouracil exposure protocols.Semantic proximity Read ↗

Epigenomics alternations and dynamic transcriptional changes in responses to 5-fluorouracil stimulation reveal mechanisms of acquired drug resistance of colorectal cancer cellsSemantic proximity Read ↗

RNA Sequencing Analysis for the Identification of Genes Associated with Cisplatin Resistance in Ovarian CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.