Back to search

Article

Prrx1b directs pro-regenerative fibroblasts during zebrafish heart regeneration

2020-06-14

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Rationale</h4> The human heart loses millions of cardiomyocytes after an ischemic injury, but is unable to regenerate the lost tissue. Instead, the injured human heart is repaired by pro-fibrotic fibroblasts that form a large permanent scar. In contrast, the injured zebrafish heart regenerates efficiently without the formation of a permanent scar. While fibroblasts have been shown to be ind...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
7ce6c56e-3711-56b2-8c42-cd396476820a
DOI
10.1101/2020.06.13.149013
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Prrx1b directs pro-regenerative fibroblasts during zebrafish heart regenerationDOI 10.1101/2020.06.13.149013
Prrx1b restricts fibrosis and promotes Nrg1-dependent cardiomyocyte proliferation during zebrafish heart regenerationSemantic proximity
Cellular drivers of injury response and regeneration in the adult zebrafish heartSemantic proximity
ptx3a+ fibroblast/epicardial cells provide a transient macrophage niche to promote heart regenerationSemantic proximity
Distinct features of the regenerating heart uncovered through comparative single-cell profilingSemantic proximity
Activation of a transient progenitor state in the epicardium is required for zebrafish heart regenerationSemantic proximity
Spatio-temporal dynamics of the fibrotic niche in cardiac repairSemantic proximity
An organ-wide spatiotemporal transcriptomic and cellular atlas of the regenerating zebrafish heartSemantic proximity
Heart repair by reprogramming non-myocytes with cardiac transcription factors.Semantic proximity
Runx1 promotes scar deposition and inhibits myocardial proliferation and survival during zebrafish heart regeneration.Semantic proximity
The Role of Cardiac Fibroblast Heterogeneity in Myocardial Fibrosis and Its Novel Therapeutic PotentialSemantic proximity
Primate heart regeneration <i>via</i> migration and fibroblast repulsion by human heart progenitorsSemantic proximity
Cardiac Fibroblast DiversitySemantic proximity
Select a neighboring publication to make it the new centre.