Article

Dysregulation of U12-Type Splicing in Lupus Neutrophils

2025-11-07

Abstract excerpt

<h4>Objective</h4> Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post-transcriptional changes in low-density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron splicing. <h4>Methods</h4> LDGs and normal-density neutrophils...

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Literature Corpus work: c76a9019-e0f0-582c-bddd-b37db9b3d235
DOI: 10.1101/2025.11.06.686965

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