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Article

Single-Cell Transcriptome Analysis of Peripheral Neutrophils From Patients With Idiopathic Pulmonary Arterial Hypertension.

Hypertension (Dallas, Tex. : 1979) - 1 Aug 2023

Zhang Rui, Zhang Ji, Zhang Yun-Long, Gong Su-Gang, Zhao Qin-Hua, Wang Xiao-Juan, Zhao Jia-Yu, Jiang Rong, Qiu Hong-Ling, Li Hui-Ting, He Jing, Liu Shao-Fei, Kuebler Wolfgang M, Wang Lan

Abstract excerpt

BACKGROUND: Idiopathic pulmonary hypertension (IPAH) is a rare and devastating disease often accompanied by persistent inflammation and immune responses. We aim to provide a reference atlas of neutrophils to facilitate a better understanding of cellular phenotypes and discovery of candidate genes. METHODS: Peripheral neutrophils from naive patients with IPAH and matched controls were profiled. Whole-exon...

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Identifiers

PMID: 37313754
DOI: 10.1161/HYPERTENSIONAHA.123.21142

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