Article
Decreased SMG7 expression associates with lupus-risk variants and elevated antinuclear antibody production.
Annals of the rheumatic diseases - 1 Nov 2016
Deng Yun, Zhao Jian, Sakurai Daisuke, Sestak Andrea L, Osadchiy Vadim, Langefeld Carl D, Kaufman Kenneth M, Kelly Jennifer A, James Judith A, Petri Michelle A, Bae Sang-Cheol, Alarcón-Riquelme Marta E, Alarcón Graciela S, Anaya Juan-Manuel, Criswell Lindsey A, Freedman Barry I, Kamen Diane L, Gilkeson Gary S, Jacob Chaim O, Merrill Joan T, Gaffney Patrick M, Sivils Kathy Moser, Niewold Timothy B, Ramsey-Goldman Rosalind, Reveille John D, Scofield R Hal, Stevens Anne M, Boackle Susan A, Vilá Luis M, Sohn I I Woong, Lee Seung, Chang Deh-Ming, Song Yeong Wook, Vyse Timothy J, Harley John B, Brown Elizabeth E, Edberg Jeffrey C, Kimberly Robert P, Cantor Rita M, Hahn Bevra H, Grossman Jennifer M, Tsao Betty P
Abstract excerpt
OBJECTIVES: Following up the systemic lupus erythematosus (SLE) genome-wide association studies (GWAS) identification of NMNAT2 at rs2022013, we fine-mapped its 150 kb flanking regions containing NMNAT2 and SMG7 in a 15 292 case-control multi-ancestry population and tested functions of identified variants. METHODS: We performed genotyping using custom array, imputation by IMPUTE 2.1.2 and allele specific...
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