Article
Application of dried blood spot sampling combined with LC-MS/MS for genotyping and phenotyping of CYP450 enzymes in healthy volunteers.
Biomedical chromatography : BMC - 1 Oct 2011
de Boer Theo, Wieling Jaap, Meulman Erik, Reuvers Mariska, Renkema Gonda, den Daas Izaak, van Iersel Thijs, Wemer Johan, Chen LingSing
Abstract excerpt
An early clinical development study (phase I) was conducted to determine the usefulness of dried blood spot (DBS) sampling as an alternative to venous sampling for phenotyping and genotyping of CYP450 enzymes in healthy volunteers. Midazolam (MDZ) was used as a substrate for phenotyping CYP3A4 activity; the concentrations of MDZ and its main metabolite 1'-hydroxymidazolam (1-OH MDZ) were compared between the DBS...
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