Article

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2

2020-04-08

Abstract excerpt

<h4>ABSTRACT</h4> Mutations that activate LRRK2 protein kinase cause Parkinson’s disease. We have shown previously that Rab10 phosphorylation by LRRK2 enhances its binding to RILPL1 and together, these proteins block cilia formation in a variety of cell types including patient derived iPS cells. We have used live cell fluorescence microscopy to identify, more precisely, the effect of LRRK2 kinase activity on both...

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Literature Corpus work: c759d317-bde8-530a-ba33-a4ac42c72327
DOI: 10.1101/2020.04.07.029983

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