Article

LRRK2 causes centrosomal deficits via phosphorylated Rab10 and RILPL1 at centriolar subdistal appendages

2021-08-24

Abstract excerpt

The Parkinson’s disease-associated LRRK2 kinase phosphorylates multiple Rab GTPases including Rab8 and Rab10, which enhances their binding to RILPL1 and RILPL2. The nascent interaction between phospho-Rab10 and RILPL1 blocks ciliogenesis in vitro and in the intact brain, and interferes with the cohesion of duplicated centrosomes in dividing cells. We show here that various LRRK2 risk variants and all currently de...

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Literature Corpus work: 80aaf7eb-b486-5315-90e4-4450fd29a39e
DOI: 10.1101/2021.08.23.457380

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