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Article

Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease.

Journal of peptide science : an official publication of the European Peptide Society - 1 May 2024

Alexander Krista K, Naaldijk Yahaira, Fasiczka Rachel, Brahmia Besma, Chen Tiancheng, Hilfiker Sabine, Kennedy Eileen J

Abstract excerpt

Familial Parkinson's disease (PD) is frequently linked to multiple disease-causing mutations within Leucine-Rich Repeat Protein Kinase 2 (LRRK2), leading to aberrant kinase activity. Multiple pathogenic effects of enhanced LRRK2 activity have been identified, including loss of cilia and centrosomal cohesion defects. When phosphorylated by LRRK2, Rab8a and Rab10 bind to phospho-specific RILPL effector proteins....

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PMID: 38135900
DOI: 10.1002/psc.3563

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Targeting Rab-RILPL interactions as a strategy to downregulate pathogenic LRRK2 in Parkinson's disease.PMID 38135900Read ↗

Targeting Rab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson’s DiseaseSemantic proximity Read ↗

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockadeSemantic proximity Read ↗

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarizationSemantic proximity Read ↗

LRRK2 causes centrosomal deficits via phosphorylated Rab10 and RILPL1 at centriolar subdistal appendagesSemantic proximity Read ↗

Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease.Semantic proximity Read ↗

Leucine-Rich Repeat Kinases.Semantic proximity Read ↗

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylationSemantic proximity Read ↗

Structural basis for Rab8a GTPase recruitment of RILPL2 <i>via</i> LRRK2 phosphorylation of switch 2Semantic proximity Read ↗

Pathogenic LRRK2 regulates ciliation probability upstream of Tau Tubulin kinase 2Semantic proximity Read ↗

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in AstrocytesSemantic proximity Read ↗

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.Semantic proximity Read ↗

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteinsSemantic proximity Read ↗

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