Article

Endogenous LRRK2 and PINK1 function in a convergent neuroprotective ciliogenesis pathway in the brain

2024-06-11

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in LRRK2 and PINK1 are associated with familial Parkinson’s disease (PD). LRRK2 phosphorylates Rab GTPases within the Switch II domain whilst PINK1 directly phosphorylates Parkin and ubiquitin and indirectly induces phosphorylation of a subset of Rab GTPases. Herein we have crossed LRRK2 [R1441C] mutant knock-in mice with PINK1 knock-out (KO) mice and report that loss of PINK1 does not...

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Literature Corpus work: c2ea1b1f-dcb9-5d2b-818a-fae597c7c1aa
DOI: 10.1101/2024.06.11.598416

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