Article

Repeated stimulation or tonic-signaling chimeric antigen receptors drive regulatory T cell exhaustion

2020-06-28

Abstract excerpt

Regulatory T cell (Treg) therapy is a promising approach to improve outcomes in transplantation and autoimmunity. In conventional T cell therapy, chronic stimulation can result in poor in vivo function, a phenomenon termed exhaustion. Whether or not Tregs are also susceptible to exhaustion, and if so, if this would limit their therapeutic effect, was unknown. We studied how two methods which induce conventional T...

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Literature Corpus work: c74fd0d0-852f-58db-a485-b89300f5ef4c
DOI: 10.1101/2020.06.27.175158

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