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Article

Tau propagation is dependent on the genetic background of mouse strains

21 Feb 2022

Abstract excerpt

Progressive cognitive decline in Alzheimer's disease correlates closely with the spread of tau protein aggregation across neural networks of the cortical mantle. We tested the hypothesis that heritable factors may influence the rate of propagation of tau pathology across brain regions in a model system, taking advantage of well-defined genetically diverse background strains in mice. We virally expressed human tau...

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PMID: 35350555
DOI: 10.1093/braincomms/fcac048

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