Article

GALR2 W248L mutation exacerbates neuroinflammation through pro-inflammatory macrophage polarization and microglial activation in experimental autoimmune encephalomyelitis

2026-07-28

Abstract excerpt

Multiple sclerosis (MS) is a chronic neuroinflammatory disease characterized by demyelination, neurodegeneration, and progressive neurological disability. Galanin, a neuropeptide with immunomodulatory properties, signals through G protein-coupled receptors, among which galanin receptor 2 (GALR2) has been implicated with neuroprotective and anti-inflammatory functions. A rare homozygous single nucleotide variant in...

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Literature Corpus work: c7378f0a-0c2f-5602-b7dc-6cf98dc2c9d2
DOI: 10.64898/2026.07.27.740554

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