Dynamic responses to rejection in the transplanted human heart revealed through spatial transcriptomics

Abstract excerpt

<h4>ABSTRACT</h4> Allograft rejection following solid-organ transplantation is a major cause of graft dysfunction and mortality. Current approaches to diagnosis rely on histology, which exhibits wide diagnostic variability and lacks access to molecular phenotypes that may stratify therapeutic response. Here, we leverage image-based spatial transcriptomics at sub-cellular resolution in longitudinal human cardiac b...

Topics

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• HIV Research and Treatment
• Renal and Vascular Pathologies
• Renal Diseases and Glomerulopathies
• Renal Transplantation Outcomes and Treatments
• Single-cell and spatial transcriptomics
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

8b7bae92-da0b-5049-ac91-525ca76106b5

DOI

10.1101/2025.02.28.640852